Research into Lesson Zero from Friendship is Magic 

Everyone reaction was the same thing over Lesson Zero 
from Friendship is Magic. Twilight Sparkle went Crazy
or Insane or some crap like that. I have been trying 
to proof that is not the Case. I found out Twilight 
Sparkle was Suffering from Panic Attacks/Anxiety/
Freaking Out/Autism Meltdowns in Lesson Zero. 

If Friendship is Magic explained Why Twilight 
Sparkle was acting and sounding this way. 
Nobody ever think Twilight Sparkle Went Crazy. 
But did the same with Pinkie Pie and Fluttershy. 
That is why Crazy Twilight Sparkle or Whatever 
people call it was born.